1.
Eur J Intern Med
; 112: 133-135, 2023 Jun.
Article
in English
| MEDLINE | ID: covidwho-20239425
2.
Clin Geriatr Med
; 38(3): 461-472, 2022 08.
Article
in English
| MEDLINE | ID: covidwho-1914223
ABSTRACT
Aging has been identified as one of the most relevant risk factors for poor outcomes in COVID-19 infection. Since now, different mechanisms responsible for worse outcomes in the elderly have been proposed, which include the remodeling of immune system, the higher prevalence of malnutrition and sarcopenia, the increased burden of multimorbidity, and, to a lesser extent, the direct effects of age on the respiratory system and hormonal profile. It seems that the interplay between all these causes, rather than the individual pathophysiological mechanism, explains the increased severity of the disease with age.